The Saints are favored by 2.5 points in the latest Eagles vs. Saints odds via SportsLine consensus, and the over/under is 49.5 points. Before entering any Saints vs. Eagles picks, you'll want to see the NFL predictions from the model at SportsLine.

Sept. 22 (kicking off at 1:00 p.m. ET), the New Orleans Saints (2-0) face the Philadelphia Eagles (1-1) at Caesars Superdome and are expected to prevail easily, 34-22 (based on our

If the Dallas victory was indicative of how the New Orleans Saints (2-0) would respond after having overwhelmed Carolina the prior week, then there shouldn't be concern about whether they'll be ready Sunday against the Eagles (1-1) in the Caesars Superdome. That doesn't guarantee a win, but here are a few things that might help in that regard: